Muhaimin, Muhaimin and Burkhard, Dickenhorst and Roland, Bodmeier PREPARATION AND CHARACTERIZATION OF POLY(Є-CAPROLACTONE) MICROPARTICLE BLENDS CONTAINING PROPRANOLOL HCl AND CARBAMAZEPINE. Proceeding of International Conference On Research, Implementation And Education Of Mathematics And Sciences 2014. (Submitted)
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Abstract
The purpose of this study was to investigate physicochemical properties of poly(є- caprolactone) microparticle blends containing drugs with different solubilities (Propranolol HCl [Pro] and carbamazepine [CBZ]). Microparticle blends were formulated with W/O/W emulsion for Pro and O/W emulsion for CBZ. The Pro emulsion (W/O) and CBZ oil phase (O) were dispersed in an external aqueous phase (W), with dispersion time interval (DTI) of 0 and 60 min. Morphology of microparticle blends were characterized by scanning electron microscopy (SEM). Particle size mean of emulsion droplets/hardened microparticles were monitored by focused beam reflectance measurement (FBRM). Encapsulation efficiency (EE) and in vitro drug release in phosphate buffer (pH 7.4) were also investigated. The results showed that the resulting microparticle blends obtained by solvent evaporation method were spherical and having two populations. FBRM data showed that the size of microparticle blends prepared with DTI 60 min and stirring time 4 h was larger than those with DTI 0 min. The encapsulation efficiency were 62.05% to 66.38% for Pro and 70.56% to 73.85% for CBZ in microparticle blends. Drug release in phosphate buffer after 28 days showed that the Pro release (33%) was slower than CBZ release (60%) from microparticle blends with DTI 60 min. This phenomenon was attributed to the interaction of oil phase (CBZ) with hard particles from primary emulsion (Pro), whereby the oil phase had blocked and coated pores on the surface of hard particle from primary emulsion.
| Item Type: | Article |
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| Uncontrolled Keywords: | microparticle blends, propranolol HCl, carbamazepine, poly(є- caprolactone), FBRM, solvent evaporation method |
| Subjects: | Prosiding > ICRIEMS 2014 > CHEMISTRY & CHEMISTRY EDUCATION |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Jurusan Pendidikan Kimia > Kimia |
| Depositing User: | Eprints |
| Date Deposited: | 06 Nov 2014 04:41 |
| Last Modified: | 06 Nov 2014 04:41 |
| URI: | http://eprints.uny.ac.id/id/eprint/11378 |
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