Lumbung Pustaka UNY: No conditions. Results ordered -Date Deposited. 2024-03-28T14:53:32ZEPrintshttp://eprints.uny.ac.id/apw_template/images/sitelogo.pnghttps://eprints.uny.ac.id/2014-11-06T04:41:13Z2014-11-06T04:41:13Zhttp://eprints.uny.ac.id/id/eprint/11378This item is in the repository with the URL: http://eprints.uny.ac.id/id/eprint/113782014-11-06T04:41:13ZPREPARATION AND CHARACTERIZATION OF
POLY(Є-CAPROLACTONE) MICROPARTICLE BLENDS
CONTAINING PROPRANOLOL HCl AND CARBAMAZEPINEThe purpose of this study was to investigate physicochemical properties of poly(є-
caprolactone) microparticle blends containing drugs with different solubilities
(Propranolol HCl [Pro] and carbamazepine [CBZ]). Microparticle blends were
formulated with W/O/W emulsion for Pro and O/W emulsion for CBZ. The Pro emulsion
(W/O) and CBZ oil phase (O) were dispersed in an external aqueous phase (W), with
dispersion time interval (DTI) of 0 and 60 min. Morphology of microparticle blends were
characterized by scanning electron microscopy (SEM). Particle size mean of emulsion
droplets/hardened microparticles were monitored by focused beam reflectance
measurement (FBRM). Encapsulation efficiency (EE) and in vitro drug release in
phosphate buffer (pH 7.4) were also investigated. The results showed that the resulting
microparticle blends obtained by solvent evaporation method were spherical and having
two populations. FBRM data showed that the size of microparticle blends prepared with
DTI 60 min and stirring time 4 h was larger than those with DTI 0 min. The
encapsulation efficiency were 62.05% to 66.38% for Pro and 70.56% to 73.85% for CBZ
in microparticle blends. Drug release in phosphate buffer after 28 days showed that the
Pro release (33%) was slower than CBZ release (60%) from microparticle blends with
DTI 60 min. This phenomenon was attributed to the interaction of oil phase (CBZ) with
hard particles from primary emulsion (Pro), whereby the oil phase had blocked and
coated pores on the surface of hard particle from primary emulsion.Muhaimin MuhaiminDickenhorst BurkhardBodmeier Roland